Plan of the Day Radiotherapy

University of Oslo (UIO)

Status

Enrolling

Conditions

Cervix Cancer

Treatments

Radiation: Standard plan

Radiation: Plan of the day

Study type

Interventional

Funder types

Other

Identifiers

NCT05634681

236807

Details and patient eligibility

About

The study objectives are to improve the treatment of LACC patients and to increase knowledge of the potential benefit of the plan-of-the-day concept on side effects during and after radiotherapy.

Enrollment

190 estimated patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically confirmed cervical cancer eligible for definitve radiochemotherapy
FIGO stage IB1-IVa
Over 18 years
Speaks and understands Norwegian or English.
ECOG 0-2
Histology: Squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma
Ability to understand and fill in patient questionnaires, and willing to sign a written informed consent
Large movers (LM), fundus movement ≥2,5 cm.

Exclusion criteria

Evidence of distant metastasis. Suspicious paraaortic lymphnodes below the renal vessels is allowed if they are covered by the radiation field
Patients with previous surgery for their cervical cancer
Uncontrolled intercurrent somatic illness.
Psychiatric illness /social situations limiting study compliance
Prior radiotherapy to the pelvis
Patients who are pregnant or breastfeeding is excluded due to risk of teratogenic and abortifacient effects of radiotherapy and cisplatin, and the potential risk of adverse effect of nursing infants
Patients under current treatment for other invasive s except non-melanoma skin cancers
Nephrostomy
Patients with inflammatory bowel disease