Plant Based Diet, Ethnicity, and the Gut Microbiome

Vanderbilt University Medical Center

Status: Completed

Conditions: Microbial Colonization; Diet Modification

Treatments: Other: Plant Based Diet

Study type: Interventional

Funder types: Other

Identifiers

NCT03314194

171170

Details and patient eligibility

About

Samples will be collected to determine human genetic variation, fecal and oral microbial communities, and metabolome products. Several evolutionary and ecological diversity metrics will be distilled to test: a) if microbiome variation within each ethnicity is less than that between ethnicities; b) if microbiome variation is finely structured according to genetic relatedness; and c) if dietary variation impacts human genome x microbiome associations.

Full description

To characterize the human gut microbiome under highly controlled dietary intake in healthy normal weight adult participants who differ by ethnicity: White non-Hispanic and Black non-Hispanic adults. Samples will be collected to determine human genetic variation, fecal and oral microbial communities, and metabolome products. Several evolutionary and ecological diversity metrics will be distilled to test: a) if microbiome variation within each ethnicity is less than that between ethnicities; b) if microbiome variation is finely structured according to genetic relatedness; and c) if dietary variation impacts human genome x microbiome associations.

Enrollment: 38 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female
• Age 18-40
• BMI 18.5-24.9
• Caucasian or African American

Exclusion criteria

• Not weight stable
• Using Medications
• Using Dietary Supplements
• Chronic Disease
• Tobacco Use
• Drug Use
• Pregnant or Lactating
• Diet Restrictions
• Vegetarian or Vegan

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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38 participants in 1 patient group

Plant Based Diet Group

Experimental group

Description:

Study aims for two cohorts of 20 females each, being tested over 6 days in two conditions: habitual diet versus plant based diet.

Treatment:

Other: Plant Based Diet