Plaque Burden and Ischemia in MINOCA

University of Bergen

Status: Enrolling

Conditions: MINOCA

Treatments: Diagnostic Test: CT coronary angiography and [12N] NH3 PET-MR

Study type: Observational

Funder types: Other

Identifiers

NCT05681858

463549

Details and patient eligibility

About

The goal of this clinical trial is to assess coronary artery plaque burden, perivascular inflammation and extent of myocardial ischemia in patients presenting with acute myocardial infarction and non-obstructive coronary artery disease. The main question it aims to answer are:

• Identify coronary artery anatomy, plaque burden, composition and high-risk plaque features by CT coronary angiography in MINOCA
• Assess presence, extent and severity of myocardial ischemia in MINOCA

Participants will examined by CT coronary angiography and stress [12N] NH3 PET-MR.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute chest pain
• Elevated troponin
• Non-obstructive coronary arteries by coronary angiography

Exclusion criteria

• Obstructive coronary artery disease
• Contraindications against CT coronary angiography or stress [12N] NH3 PET-MR
• Not able to give informed consent

Trial design

100 participants in 1 patient group

CT coronary angiography and [12N] NH3 PET-MR

Description:

All patients will undergo CT coronary angiography and stress \[12N\] NH3 PET-MR

Treatment:

Diagnostic Test: CT coronary angiography and [12N] NH3 PET-MR