Plasma Adiponectin Concentration, Activity and Isoforms in Newly Diagnosed and Untreated Type 2 Diabetes Mellitus

Air Force Military Medical University of People's Liberation Army

Status: Unknown

Conditions: Diabetes Mellitus

Study type: Observational

Funder types: Other

Identifiers

NCT01372852

xjyy110501

Details and patient eligibility

About

The objective of present study were to compare plasma adiponectin isoform status, their bioactivities newly diagnosed Chinese with healthy volunteer.

Full description

Adiponectin, circulates as trimer, hexamer and high molecular weight form (HMW) in human blood, is a promising biomarker for indication diabetes and cardiovascular disease. Both adiponectin complexes concentration and their bioactivities are decreased in pathological state. Disulfide-bond A oxidoreductase-like protein (DsbA-L) is a key regulator for adiponectin biosynthesis and its expression level is down-regulated in obese mice and humans. However, the alteration of circulating adiponectin multimers distribution, their bioactivities and adiponectin regulator, DsbA-L level, in newly diagnosed Chinese type 2 diabetes patients are unknown. The objective of present study were to compare plasma adiponectin isoform status, their bioactivities and DsbA-L concentration in newly diagnosed Chinese with healthy volunteer.

Enrollment: 300 estimated patients

Sex: All

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Having a diabetic history within 12 months
• BMI smaller than 30kg/m2

Exclusion criteria

• Having any kinds of treatment affecting glucose
• pregnant
• uncontrolled hypertension, active cardiac disease, or other major liver, kidney disease

Trial design

300 participants in 2 patient groups

T2DM patients

Description:

newly diagnosed T2DM patients and untreated with any drugs.

Non-diabetic Control Group