Plasma Biomarkers in Cardiac Valve Surgery

University of Liege

Status: Unknown

Conditions: Elective Valvular Cardiac Surgery

Treatments: Procedure: Cardiac valve surgery

Study type: Observational

Funder types: Other

Identifiers

NCT02641665

2016001

Details and patient eligibility

About

The level of four biomarkers will be measured in the patients' plasma after induction of anaesthesia. There biomarkers are NT-ProBNP, ST2, Galectin-3 and GDF-15. The level of these marker will then be correlated with early (30 days) and late (one year) patients' prognosis and with functional recovery (MLHFQ score).

Enrollment: 250 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Elective/urgent aortic or mitral valve surgery in isolation or combined with CABG

Exclusion criteria

• Emergency or salvage surgery
• Inability to consent
• Previous cardiac surgery
• Stage IV or V CDK (GFR ≤ 30 ml/min) or dialysis
• Active Endocarditis
• Liver cirrhosis
• Chronic atrial fibrillation
• Pacemaker