Plasma Biomarkers of Cardiopulmonary Bypass Induced Acute Respiratory Distress Syndrome (CPB-ARDS) (PBOARDS)

H

Huazhong University of Science and Technology

Status

Completed

Conditions

Acute Respiratory Distress Syndrome

Study type

Observational

Funder types

Other

Identifiers

NCT04696172
V1.0

Details and patient eligibility

About

The investigators aimed to establish a prospective cohort of patients undergoing cardiopulmonary bypass (CPB) in cardiac surgery from April 2021 to September 2022, in Wuhan. The ARDS events, ventilation time, time of extubation, oxygenation index for 3 days after operation were observed. Plasma samples were collected before CPB, and several time points after CPB. Dynamic differential proteins of ARDS after CPB were screened by DIA (Data independent acquisition) proteomics. Quantitative protein marker concentration was used to predict the occurrence of ARDS after operation, the model discrimination and calibration was assessed.

Enrollment

525 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Selective operation;
  • Cardiac surgery with cardiopulmonary bypass;
  • Adult patients over 18 years old;
  • Signed informed consent

Exclusion criteria

  • patients who refuse to sign the informed consent form or the attending physician refuses the patient to join the study;
  • non elective surgery (surgery at non-elective time or emergency surgery);
  • preoperative pulmonary insufficiency, pulmonary hypertension and pulmonary inflammation;
  • the absence of any specimen and clinical data;
  • patients who failed the operation, needed extracorporeal membrane oxygenation support or underwent CPB operation again within 3 days after operation;

Trial design

525 participants in 2 patient groups

Patients undergoing cardiopulmonary bypass (CPB) with postoperative ARDS
Patients undergoing cardiopulmonary bypass (CPB) without postoperative ARDS

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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