Plasma Concentrations of Bupivacaine After Peri-articular Injection in Total Knee Arthroplasty

Mahidol University

Status and phase: Completed; Phase 4

Conditions: Serum Bupivacaine Level; Total Knee Arthroplasty; Periarticular Block

Treatments: Drug: Bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT01636869

010/2555

Details and patient eligibility

About

Patients with knee arthroplasty usually performed under spinal anesthesia with a single-shot femoral nerve block and periarticular block, so we would like to know the plasma concentration of bupivacaine in these patients.

Enrollment: 43 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age of 30-70 yr
• ASA I-II
• patient undergo total knee arthroplasty under spinal block and single shot femoral nerve block and periarticular block

Exclusion criteria

• patient's refusal
• allergic to bupivacaine
• body weight less than 50 kg
• liver disease
• heart disease
• coagulopathy
• Hct<35%
• infection at both groin

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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43 participants in 1 patient group

bupicavaine

Experimental group

Treatment:

Drug: Bupivacaine