Plasma Exchange vs Conservative Management in Non-severe Acute Hypertriglyceridemic Pancreatitis

University Medical Centre Ljubljana

Status: Completed

Conditions: Acute Pancreatitis

Treatments: Drug: conservative treatment; Procedure: plasma exchange

Study type: Interventional

Funder types: Other

Identifiers

NCT02622854

HiperlipPankr

Details and patient eligibility

About

To compare effectiveness in reducing triglycerides between daily plasma exchange and glucose+insulin infusion in patients with non-severe acute hypertriglyceridemic pancreatitis with mildly elevated triglycerides

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• mild acute hypertriglyceridemic pancreatitis
• triglycerides >15 but < 40 mmol/l

Exclusion criteria

• pregnancy
• severe course of pancreatitis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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22 participants in 2 patient groups

plasma exchange

Experimental group

Description:

plasma exchange, with 1.5 estimated plasma volume exchanged with albumin solution, using citrate anticoagulation, performed daily until triglycerides \<=10 mmol/l

Treatment:

Procedure: plasma exchange

conservative treatment

Active Comparator group

Description:

infusion of 5% glucose and insulin, to maintain blood glucose at 5-8 mmol/l

Treatment:

Drug: conservative treatment