Plasma Marine n-3 Polyunsaturated Fatty Acids and Patient and Graft Survival

University of Oslo (UIO)

Status: Completed

Conditions: Disorder of Transplanted Kidney

Study type: Observational

Funder types: Other

Identifiers

NCT02017990

REK 2012/1419

Details and patient eligibility

About

This study will evaluate the association between n-3 polyunsaturated fatty acids and patient and graft survival. The association between other fatty acids and mortality and graft loss endpoints will also be evaluated.

Full description

This observational study focuses on the effects of marine n-3 polyunsaturated fatty acids (PUFAs) intake, measured as fatty acid levels in plasma phospholipids, and mortality and graft loss endpoints in renal transplant recipients. Data on morbidity, mortality and graft loss in The Norwegian Renal Registry is matched against data on fatty acid composition in a large renal transplantation cohort of approximately 2000 patients with a median follow up time of about 5 years. It is a follow up study, although retrospectively evaluated. It will evaluate the role of marine n-3 PUFAs as a prognostic marker in renal transplantation by investigating the association between the levels (weight percentage of total fatty acids) of marine n-3 PUFAs in plasma phospholipids and events, including mortality and graft loss.

Enrollment: 2,002 patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Received a renal transplant. Signed informed consent.

Exclusion criteria

• Under the age of 16 years.

Trial design

2,002 participants in 1 patient group

Renal transplant recipients

Description:

No intervention. Measurements of plasma marine n-3 polyunsaturated fatty acids levels, indicating intake of fish and seafood.