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The investigators plan to understand a comprehensive molecular profiling via the plasma, with the primary aim of using this form on analysis to guide subsequent treatment selection. This study will provide a better understanding of ALK resistance in the treatment of Asian lung cancers and allow for improved clinical outcomes by 'matching' the secondary mutations to an ALK inhibitor which would allow for the greatest coverage ultimately leading to lasting duration of response.
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Inclusion criteria
Patients with advanced ALK fusion oncogene positive lung adenocarcinoma that have progressed after 1-2 ALK inhibitors, with at least one prior line of 2nd generation ALKi (i.e. Ceritinib, Alectinib, Brigatinib or Ensartinib)
The availability of sufficient plasma
Age ≥ 21 years
WHO performance status ≤ 2
Life expectancy of ≥ 21 weeks
Patients should have adequate organ function for potential consideration into clinical trials (routine blood tests are valid within 14 days before enrollment):
Willing to provide signed informed consent
Patients whom do not fulfill the above criteria may be discussed on a case-by-case basis within the study team, for potential enrolment
Exclusion criteria
50 participants in 2 patient groups
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Central trial contact
Cherlyn Shepherdson
Data sourced from clinicaltrials.gov
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