Plasma Neutrophil Gelatinase Associated Lipocalin Levels During Emergency Management of Rhabdomyolysis

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Rhabdomyolysis; Acute Kidney Failure

Treatments: Biological: Plasma NGAL level

Study type: Observational

Funder types: Other

Identifiers

NCT01544231

2011-A01059-32 (Other Identifier)

PHRC-I/2011/SP-03

Details and patient eligibility

About

This research project consists of a prospective diagnostic study conducted on patients with clinical suspicion of rhabdomyolysis admitted to the emergency rooms of the University Hospitals of Nimes, Montpellier, Paris, Nice and Toulon Inter Army Hospital. The main objective of this study is to determine whether the plasma level of Neutrophil Gelatinase Associated Lipocalin (NGAL) may be retained as a predictor of acute renal failure (ARF) occurring within 48 hours after admission for rhabdomyolysis.

Full description

The secondary objectives of this are:

• to study plasma NGAL levels on admission to the emergency ward as a marker of morbidity and mortality by considering the following factors: duration of hospitalization, need for extracorporeal blood purification, ICU admission, death.
• to study the delay between the onset of the proposed cause of rhabdomyolysis and treatment initiation
• to study the delay between treatment initiation and the occurrence of ARF.

Enrollment: 197 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patient must have given his/her informed and signed consent
• The patient must be insured or beneficiary of a health insurance plan
• Patient hospitalized with Creatine Phospho-Kinase > 1000 UI/l

Exclusion criteria

• The patient is participating in another study
• The patient is in an exclusion period determined by a previous study
• The patient is under judicial protection, under tutorship or curatorship
• The patient refuses to sign the consent
• It is impossible to correctly inform the patient
• The patient is pregnant, parturient, or breastfeeding
• Chronic renal insufficiency with dialysis
• The patient has an acute coronary syndrome
• Nephrotoxic medications within 72 hours prior to admission
• Need for a procedure involving the injection of iodine
• Patient in shock
• Occurrence of acute renal failure can be explained by a cause other than rhabdomyolysis.

Trial design

197 participants in 1 patient group

Patients

Description:

Adult patients with suspected rhabdomyolysis admitted to the participating University Hospital emergency rooms (see inclusion/exclusion criteria).

Treatment:

Biological: Plasma NGAL level