Plasma Rich in Growth Factors in Post-extraction Sockets

University of Granada (UGR)

Status: Active, not recruiting

Conditions: Tooth Extraction; Dental Implants

Treatments: Device: PRGF; Device: ABB

Study type: Interventional

Funder types: Other

Identifiers

NCT03943680

1962-N-18

Details and patient eligibility

About

The purpose of this study is to compare the clinical success, radiographical volume maintenance and histological bone regeneration after using either a bovine bone xenograft or an autogenous platelet rich plasma enrich in growth factors, known as Endoret®-PRGF®.

Enrollment: 30 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Upper or lower premolar or molar tooth in need of extraction and later restoration by dental implant.
• Adjacent and opposing natural teeth present and healthy.
• At least 3 mm from the tip of the dental root to the maxillary sinus or the inferior alveolar canal.

Exclusion criteria

• Active local infection.
• Uncontrolled diabetes mellitus.
• Long term (>10 years) use of oral bisphosphonates.
• Use of intravenous bisphosphonates.
• Recent use (<3 months) of antibiotics, antiinflammatories or analgesics drugs.
• Pregnancy.
• Smokers of more than 10 cigarettes per day.
• Any oral pathology that needs to be treated before tooth extraction, particularly the presence of more than 25% of sites with bleeding on probing.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

PRGF

Experimental group

Description:

Post-extraction socket grafted with PRGF-Endoret

Treatment:

Device: PRGF

ABB

Active Comparator group

Description:

Post-extraction socket grafted with anorganic bovine bone (ABB)

Treatment:

Device: ABB