Plasmalyte-148 Solution and Blood Coagulation

Seoul National University

Status: Completed

Conditions: Blood Coagulation Disorder

Treatments: Other: Plasmalyte-148

Study type: Observational

Funder types: Other

Identifiers

NCT03168087

B-1705/395-303

Details and patient eligibility

About

Fluids administered intravenously may alter whole blood coagulation. However, little is known about the dose-response relationships of hemodilution in plasmalyte-148 solution. Investigators have therefore performed the present study to measure the effect of a plasmalyte-148 solution on the coagulation pathway according to the hemodilution level using a rotational thromboelastometry (ROTEM®) tests.

Enrollment: 12 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• Age: 20 to 65 years
• Body weight > 50 kg
• Volunteers who provided informed consent

Exclusion criteria

• Hematologic disease
• Anticoagulant medication

Trial design

12 participants in 4 patient groups

0% dilution

Description:

Blood specimen which was diluted with 0% level using a plasmalyte-148 solution

20% dilution

Description:

Blood specimen which was diluted with 20% level using a plasmalyte-148 solution

Treatment:

Other: Plasmalyte-148

40% dilution

Description:

Blood specimen which was diluted with 40% level using a plasmalyte-148 solution

Treatment:

Other: Plasmalyte-148

60% dilution

Description:

Blood specimen which was diluted with 60% level using a plasmalyte-148 solution

Treatment:

Other: Plasmalyte-148