Plasticity of Neonatal Neuronal Networks Temporal Theta Activity, the First Endogenous (NEURONAUX)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Premature Birth

Treatments: Other: ElectroEncephaloGraphy

Study type: Observational

Funder types: Other

Identifiers

NCT03677908

PI2017_843_0048

Details and patient eligibility

About

Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing and cortical network functioning. The role in development and the precise location of TTA-SW remain unknown. Previous studies have demonstrated that preterms from 28 weeks of gestational age (wGA) are able to discriminate phonemes and voice, supporting the idea of a prior genetic structural or activity-dependent fingerprint that would prepare the auditory network to compute auditory information at the onset of thalamocortical connectivity. They recorded TTA-SW in 26-32 wGA preterms. The rate of TTA-SW in response to click stimuli was evalu- ated using low-density EEG in 30 preterms. The sources of TTA-SW were localized by high-density EEG using different tissues conductivities, head models and mathematical models.

Full description

Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing and cortical network functioning. The role in development and the precise location of TTA-SW remain unknown. Previous studies have demonstrated that preterms from 28 weeks of gestational age (wGA) are able to discriminate phonemes and voice, supporting the idea of a prior genetic structural or activity-dependent fingerprint that would prepare the auditory network to compute auditory information at the onset of thalamocortical connectivity. They recorded TTA-SW in 26-32 wGA preterms. The rate of TTA-SW in response to click stimuli was evalu- ated using low-density EEG in 30 preterms.

Enrollment: 28 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• healthy premature infants
• Gestational Ages of 26 and 32 wGA

Exclusion criteria

• unhealthy premature infants

Trial design

28 participants in 2 patient groups

13 high

Description:

High-Density ElectroEncephaloGraphy analysis of 13 healthy premature infants

Treatment:

Other: ElectroEncephaloGraphy

15 low

Description:

Low-Density ElectroEncephaloGraphy analysis of other 15 healthy premature infants

Treatment:

Other: ElectroEncephaloGraphy