Plasticizers and in Vitro Fertilization Outcomes

Kaohsiung Veterans General Hospital

Status: Completed

Conditions: Fertilization in Vitro

Treatments: Other: Phthalate metabolites measurement

Study type: Observational

Funder types: Other

Identifiers

NCT03733912

VGHKS18-CT3-09

Details and patient eligibility

About

To investigate the effect of Plasticizer metabolites concentration on the in vitro fertilization outcomes

Full description

This study was conducted in a medical center in southern Taiwan. 80 infertile female patients, aged 30 to 40 years old with normal ovarian function, receiving IVF treatment in the infertility outpatient were enrolled in this study. The participates were divided into two groups: successful pregnancy in the IVF cycle (n = 40) and non-pregnancy in the IVF cycle (n = 40). After getting the consent of the patients, we plan to do a questionnaire survey. Additionally, environmental dust and urine were sampled and analyzed the concentration of plasticizers metabolites.The aim of this study is to investigate the effect of Plasticizer metabolites concentration on the in vitro fertilization outcomes.

Enrollment: 80 patients

Sex: Female

Ages: 30 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infertile women undergoing in vitro fertilization cycles
• Normal ovarian reserve (AMH > 1.0 and AFC ≧ 5)

Exclusion criteria

• Daily homestay time > 12 hrs
• Diminished ovarian reserve (AMH ≦ 1.0 or AFC<5)
• Oophorectomy
• Gynecologic cancer patients
• Severe male infertility

Trial design

80 participants in 2 patient groups

Pregnancy

Description:

Infertile women undergoing in vitro fertilization cycle got pregnancy successfully. The pregnancy persisted over 12 weeks.

Treatment:

Other: Phthalate metabolites measurement

Non-pregnancy

Description:

Infertile women undergoing in vitro fertilization cycle failed to reach pregnancy.

Treatment:

Other: Phthalate metabolites measurement