Platelet Aggregation and Adenosine Levels Among Patients Taking Ticagrelor or Prasugrel

University of Sao Paulo

Status and phase: Completed; Phase 4

Conditions: Coronary Artery Disease

Treatments: Drug: Ticagrelor; Drug: Prasugrel

Study type: Interventional

Funder types: Other

Identifiers

NCT05247385

4086/14/066 (Other Identifier)

Details and patient eligibility

About

Prospective, single-center, double blind, double dummy, randomized trial. Platelet function tests and adenosine levels were assessed at baseline and 15 days after taking Ticagrelor with Prasugrel placebo or Prasugrel with Ticagrelor placebo in stable patients with coronary artery disease

Full description

This was a prospective, double blinded, randomized trial that compared platelet inhibition and adenosine levels with ticagrelor (180mg loading dose, followed by 90 mg BID) versus prasugrel (60mg loading dose, followed by 10 mg QD) .

Patients were eligible if they were between 18 and 75 years old, were on aspirin without P2Y12 inhibitor at baseline and > 1 year after documented ACS. Platelet aggregation was compared with the Multiplate ADP® assay, performed at baseline and after 15 days on study medication. Adenosine plasma levels were measured with high performance liquid chromatography at the same time points

Enrollment: 87 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• between 18 and 75 years old
• were on aspirin
• without P2Y12 inhibitor at baseline
• > 1 year after documented acute coronary syndrome

Exclusion criteria

• use of oral anticoagulation or P2Y12 at baseline
• Weight < 60kg
• History of tia or stroke
• Any coagulation disorders
• Refuse to sign the written consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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87 participants in 2 patient groups

Prasugrel group

Active Comparator group

Description:

Prasugrel (60mg loading dose, followed by 10 mg QD for 15 days) + Ticagrelor placebo (Placebo loading dose followed by two pills a day)

Treatment:

Drug: Prasugrel

Drug: Ticagrelor

Ticagrelor group

Active Comparator group

Description:

Ticagrelor (180mg loading dose, followed by 90 mg BID) + Prasugrel placebo (Placebo loading dose followed by one pill a day)

Treatment:

Drug: Prasugrel

Drug: Ticagrelor