Platelet Count（PC）/Spleen Diameter(SD) Ratio to Predict the Variceal Haemorrhage in HBV Cirrhotic Patients in China

Shanghai Jiao Tong University

Status: Completed

Conditions: Platelet Count/Spleen Diameter Ratio; Child-Pugh Classification

Treatments: Other: Platelet count/spleen diameter ratio

Study type: Observational

Funder types: Other

Identifiers

NCT02546414

RJLIJINHUI-2015

Details and patient eligibility

About

To validate the PC/SD ratio to be used to predict the variceal haemorrhage in Chinese patients with hepatitis B virus (HBV)-associated hepatic cirrhosis.

Full description

Esophageal variceal bleeding remains the leading cause of acute mortality in patients with cirrhosis. Using noninvasive parameters for high-risk variceal haemorrhage may reduce the need for endoscopies. The ratio of platelet count/diameter of the spleen (PC/SD ratio) is the principal noninvasive predictor of esophageal varices. This was an analytical cross-sectional study to validate the diagnostic test for HBV hepatic cirrhosis and was performed between January 2013 and August 2015. This study is to validate the PC/SD ratio to identification of those patients with high bleeding risk and selection for prophylactic treatment.

Enrollment: 150 patients

Sex: All

Ages: 45 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with a diagnosis of HBV hepatic cirrhosis

Exclusion criteria

• Patients with hepatocellular carcinoma,
• use of medications for the primary prophylaxis of variceal bleeding,
• history of esophageal variceal bleeding,
• alcohol consumption within the admission and a history of ligation,
• sclerotherapy, and/or
• portal hypertension surgery

Trial design

150 participants in 3 patient groups

Esophageal varices haemorrhage group

Description:

HBV hepatic cirrhosis with first esophageal varices haemorrhage were included and stratified using their Child-Pugh score. The platelet count were evaluated, and ultrasound was used to measure the longest diameter of the spleen. The platelet count(PC)/spleen diameter (SD)ratio was calculated and analyzed to determine whether it can predict the variceal haemorrhage. Upper gastrointestinal endoscopy was used as the gold standard.

Treatment:

Other: Platelet count/spleen diameter ratio

no haemorrhage but esophageal varice presence

Description:

HBV hepatic cirrhosis with no esophageal varices haemorrhage were included and upper gastrointestinal endoscopy were validate.They also stratified using their Child-Pugh score. The platelet count and longest diameter of the spleen were evaluated, The PC/SD ratio was calculated and analyzed to determine whether it can predict the variceal presence.

Treatment:

Other: Platelet count/spleen diameter ratio

no esophageal varice but cirrhotic

Description:

HBV hepatic cirrhosis with no esophageal varices were included and also validated by upper gastrointestinal endoscopy.They stratified using their Child-Pugh score. The platelet count and longest diameter of the spleen were evaluated,The PC/SD was calculated and analyzed to determine whether it can predict the variceal absence .

Treatment:

Other: Platelet count/spleen diameter ratio