Platelet Enzymatically Oxidized Phospholipids (eoxPL) Characterisation in a Healthy Cohort on and Off Aspirin

Cardiff University

Status

Completed

Conditions

Platelet Dysfunction Due to Aspirin

Treatments

Drug: Aspirin

Study type

Interventional

Funder types

Other

Identifiers

NCT05604118

SMREC16/02

Details and patient eligibility

About

Healthy volunteers (n = 28) were recruited from the workplace (14 male, 14 female; age range 20-50 years). Ethical approval, which included informed consent, was from Cardiff University, Schools of Medicine and Dentistry Research Ethics Committee (SMREC16/02). Following a 2-week period free from non-steroidal anti-inflammatory drugs (NSAIDs), peripheral blood was obtained and platelets isolated. Participants were commenced on aspirin 75 mg once daily for seven days and then provided a repeat blood sample. Following a 2-month period, participants were invited to repeat samples pre- and post-aspirin, and again a third time 2 months later.

Enrollment

28 patients

Sex

All

Ages

20 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

two-week washout period from any non-steroidal anti-inflammatory drugs (NSAIDs) use.
Ability to take aspirin 75 mg once daily for seven days and sampled thereafter, before stopping the aspirin.
Willingness to repeat this process after two months and four months of the initial sampling date.

Exclusion criteria

* Recent NSAID use