Platelet Function and Neurological Events (MULTINEUR)

Scientific Institute San Raffaele

Status: Enrolling

Conditions: Stroke, Acute; Carotid Artery Diseases

Treatments: Diagnostic Test: Platelet Aggregometry Testing

Study type: Observational

Funder types: Other

Identifiers

NCT05572320

CE:83/INT/2022

Details and patient eligibility

About

Several studies have shown an association between platelet function and stroke in patients undergoing carotid thromboendarterectomy (TEA).

The present study will assess the correlation between platelet function evaluated by the impedance aggregometry and neurological events in patients undergoing carotid TEA.

Full description

Carotid thrombendarterectomy (TEA) is effective in preventing strokes which are a major cause of mortality and morbidity. Nevertheless, almost 10% of patients undergoing TEA develop a transient and/or permanent neurological injury. There is a growing body of evidence that platelet function is associated with perioperative neurological events in this setting, although the vast majority of patients undergoing carotid TEA are already on antiplatelet agents. The aim of the present study will be to assess the correlation between the platelet function evaluated by the impedance aggregometry (Multiplate ® Analyzer, Roche, Basel, Switzerland) and neurological events in patients undergoing carotid TEA.

Enrollment: 386 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Carotid Artery Diseases undergoing carotid thrombendarterectomy
• Signed consent

Exclusion criteria

• Atrial fibrillation
• New oral anticoagulant
• Oral Vitamin k inhibitors
• Platelet count <80000 per microliter
• Ongoing ischemic stroke