Platelet Hyperreactivity Project (PHP)

Pierre Fontana

Status: Completed

Conditions: Platelet Reactivity

Study type: Observational

Funder types: Other

Identifiers

NCT00976196

08-104

Details and patient eligibility

About

The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients.

Full description

The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients using a system biology approach that include proteomics analysis of selected platelet sub-fractions in patients displaying extreme phenotype.

Main objective:

• to characterize the proteome profile of platelet hyperreactivity in aspirin-treated cardiovascular patients

Secondary objectives:

• to characterize the platelet hyperreactivity phenotype in cardiovascular patients treated with aspirin
• to determine genetic polymorphisms associated with platelet hyperreactivity

Enrollment: 110 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Documented symptomatic ischemic atherothrombotic disease treated by aspirin.

Exclusion criteria

• Known platelet disorder
• Chronic treatment by antiplatelet drugs other than aspirin
• Chronic anticoagulant treatment
• Chronic non steroidal anti-inflammatory drug treatment
• Active cancer
• Treatment with serotonin reuptake inhibitors