Platelet Indices and WBCs to MPV Ratio in Correlation With Angiographic Profiling of Myocardial Infarction With Non-Obstructive Coronary Arteries and Its Short-Term Outcomes

Sohag University

Status

Completed

Conditions

Obstructive Coronary Arteries

Short-Term Outcomes

Myocardial Infarction

Platelet Indices

White Blood Cell

Mean Platelet Volume

Treatments

Other: Coronary Angiography

Other: SYNTAX Score

Study type

Observational

Funder types

Other

Identifiers

NCT07076732

Soh-Med-25-1-1PD

Details and patient eligibility

About

This study aims to evaluate the role of platelet indices and the [White blood cell (WBC) /mean platelet volume (MPV)] ratio in correlation with angiographic profiles of patients diagnosed with myocardial infarction with non-obstructive coronary arteries (MINOCA) to assess their predictive value for short-term clinical outcomes.

Full description

Globally, ischemic heart disease remains a significant cause of death, and its prevalence constantly increases. Around 5-15% of acute myocardial infarction (AMI) patients show nonobstructive (<50% stenosis) coronary arteries, named myocardial infarction with nonobstructive coronary arteries (MINOCA).

There are two main phases of inflammation during myocardial infarction: the inflammatory phase and the proliferative phase. The white blood cell (WBC) count and its subtypes have been investigated as potential predictors of cardiovascular outcomes in patients with coronary artery disease (CAD), serving as inflammatory markers.

The mean platelet volume (MPV) is determined in the progenitor cell, the bone marrow megakaryocyte. The platelet volume is found to be associated with cytokines (thrombopoietin, interleukin-6, and interleukin-3) that regulate megakaryocyte ploidy and platelet number and result in the production of larger platelets.

Enrollment

80 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥18 years old.
Both sexes.
Patients with acute myocardial infarction (AMI). Myocardial infarction with nonobstructive coronary arteries (MINOCA) is diagnosed if a patient fulfilled the AMI criteria in the absence of obstructive coronary arteries (type I: <50% stenosis; or type II: no stenosis) as recommended by the recent American Heart Association statement that introduces an updated definition incorporating the 4th universal MI definition, which by agreement excludes Takotsubo syndrome and myocarditis from the eventual diagnosis of MINOCA.

Exclusion criteria

Previous history of MI or coronary revascularization (PCI or bypass surgery) with acute/chronic infection.
Autoimmune diseases.
Systemic inflammatory disease.
Patients on treatment therapy which critically affects inflammatory cell count.
Patients with malignancy.
Chronic kidney disease.
Severe liver disease.
Severe anemia.
Fever (>38°C).