Platelet Inhibition by Aspirin, Acetaminophen and NSAID

Kantonsspital Graubünden

Status: Completed

Conditions: Hemostasis

Treatments: Drug: Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT00536068

KGWR0206

Details and patient eligibility

About

Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.

Full description

An in vivo study on healthy volunteers with combinations of well established drugs

Enrollment: 11 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers

Exclusion criteria

• Administration of drugs affecting platelets
• History of bleeding
• Gastrointestinal disorders
• Hypersensitivity to aspirin and/or NSAID
• Pregnancy and breast feeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

11 participants in 1 patient group

1, 2, 3, 4

Experimental group

Description:

1. acetylsalicylic acid 100 mg/po,acetaminophen 3x1g/po 2. acetylsalicylic acid 100 mg/po,diclofenac 3x50mg/po 3. acetylsalicylic acid 100 mg/po,naproxen 3x250mg/po 4. acetylsalicylic acid 100 mg/po,placebo 3x1/po

Treatment:

Drug: Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo