Platelet Reactivity in Septic Shock

Università degli Studi di Ferrara

Status: Completed

Conditions: Thrombocytopenia; Disseminated Intravascular Coagulation; Platelet Aggregation; Septic Shock; Sepsis

Treatments: Diagnostic Test: platelet responsiveness evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT03716310

Sepsisplt

Details and patient eligibility

About

Coagulation disorders and thrombocytopenia are common in patients with septic shock. Despite the clinical relevance of sepsis-induced thrombocytopenia, few studies have focused on the prediction of thrombocytopenia in this setting. The aim of this study was to evaluate whether platelets aggregometry and markers of platelets activation, such as mean platelet volume or platelet volume distribution width, could predict sepsis-induced thrombocytopenia in patients with septic shock and normal platelet count on the day of diagnosis.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of septic shock
• platelet count >150*103/mcL.

Exclusion criteria

• age <18 years
• history of any hematologic disorder
• chronic liver failure
• previous chemotherapy
• transfusion of platelet during the previous 4 weeks
• renal replacement therapy before ICU admission
• history of antiplatelet therapy during the 8 days before inclusion
• history of heparin-induced thrombocytopenia (HIT) or other acquired or induced thrombocytopenia
• occurrence of HIT (defined as HIT score over 3)
• active bleeding

Trial design

30 participants in 1 patient group

septic shock patients

Description:

Inclusion criteria of the study were diagnosis of septic shock and a platelet count \>150\*103/mcL.

Treatment:

Diagnostic Test: platelet responsiveness evaluation