Platelet-Rich and Concentrated Platelet-Poor Plasma to Reduce Air Leak Post-Lobectomy: A Randomized Controlled Trial

Zimmer Biomet

Status: Completed

Conditions: Lung Cancer

Treatments: Procedure: Standard post-lobectomy wound care; Procedure: Standard post-lobectomy wound care plus use of PRP and PPPc prepared by GPS and Plasmax respectively

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00665912

BBI-004

Details and patient eligibility

About

The purpose of this study is to determine whether the use of platelet-rich plasma (PRP) and concentrated platelet-poor plasma (PPPc) can reduce the duration of post-operative air leak after lobectomy for lung tumours.

Enrollment: 204 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients requiring a lobectomy

Exclusion criteria

• Pneumonectomy
• Sleeve lobectomy
• Determination of unresectability (prior to the initiation of lobectomy)
• Wedge resection alone

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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204 participants in 2 patient groups

1

Other group

Description:

Standard post-lobectomy wound care plus use of PRP and PPPc in the thoracic cavity.

Treatment:

Procedure: Standard post-lobectomy wound care plus use of PRP and PPPc prepared by GPS and Plasmax respectively

2

Active Comparator group

Description:

Standard post-lobectomy wound care in the thoracic cavity

Treatment:

Procedure: Standard post-lobectomy wound care