Platelet Rich Fibrin and Concentrated Growth Factors on Osseointegration of Immediate Implants

Hams Hamed Abdelrahman

Status: Completed

Conditions: Tooth Extraction; Dental Implants

Treatments: Procedure: Platelet-Rich Fibrin (PRF); Procedure: Concentrated Growth Factors (CGF)

Study type: Interventional

Funder types: Other

Identifiers

NCT05101954

PRF_GF_2019/2020

Details and patient eligibility

About

This study will involve 14 patients with mandibular premolars indicated for extraction and immediate replacement. The patients will be randomly allocated into two groups and each patient will receive one implant. In Group A, a CGF membrane will be laid in the implant cavity. While in Group B, a PRF membrane will be laid in the implant cavity. Bone graft material will be applied to fill the empty parts of the socket.

Resonance frequency measurement will be done using the OSTELL device intraoperatively, at the 1st week and after 3 months. Cone-beam computed tomography will be done preoperatively, immediately following surgery, and after 3 months

Enrollment: 14 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cooperative patients with good oral hygiene.
• Patients having a history of mandibular premolars indicated for extraction and immediate replacement.

Exclusion criteria

• Heavy smokers.
• Parafunctional occlusal habits.
• Uncontrolled diabetes.
• History of chemotherapy or radiotherapy.
• Hematological disorders that prevent either implantation or centrifugation.
• Pregnancy.
• The nee¬d for additional augmentation or previous augmentation of the same region.
• Chronic periapical pathology

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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14 participants in 2 patient groups

Group A

Experimental group

Treatment:

Procedure: Concentrated Growth Factors (CGF)

Group B

Active Comparator group

Treatment:

Procedure: Platelet-Rich Fibrin (PRF)