Platelet-rich Fibrin and Connective Tissue Graft in Recession Treatment

Kırıkkale University

Status: Completed

Conditions: Gingival Recession

Treatments: Procedure: coronally advanced flap; Biological: platelet-rich fibrin; Procedure: connective tissue graft

Study type: Interventional

Funder types: Other

Identifiers

NCT02397122

KirikkaleU

Details and patient eligibility

About

The aim of the trial is to evaluate the effectiveness of coronally advanced flap (CAF)+connective tissue graft(CTG)+platelet-rich fibrin(PRF) combination in Miller I and II recession treatment by comparing with CAF+CTG. 40 patients were surgically treated either with CAF+CTG+PRF (test group) or CAF+CTG (control group). Clinical parameters of plaque index (PI), gingival index (GI), vertical recession (VR), probing depth (PD), attachment level (AL), keratinized tissue width (KTW), horizontal recession (HR), MGJ localization (L-MGJ), tissue thickness (TT) were recorded at baseline, 3 months (PS1) and 6 months (PS2) post-surgery. Root coverage (RC), complete RC (CRC), attachment gain (AG), and keratinized tissue change (KTC) were also calculated.

Full description

Given the encouraging effects of platelet-rich fibrin (PRF) in healing and regeneration, it has been hypothesized that PRF might develop the outcomes obtained with coronally advanced flap (CAF)+connective tissue graft(CTG). Therefore, it was aimed to evaluate the effectiveness of CAF + CTG + PRF in Miller Class I and II recession defect treatment by comparing the outcomes with CAF + CTG in a preliminary, controlled, randomized clinical trial (RCT) with a 6-month follow-up. The study was conducted with 40 patients randomly grouped in half shares into indicated study groups. After phase I therapy, clinical variables including plaque index (PI), gingival index (GI), vertical recession (VR), probing depth (PD), attachment level (AL), keratinized tissue width (KTW), horizontal recession (HR), MGJ localization (L-MGJ), tissue thickness (TT) were recorded. The surgical sites were prepared by using sulcular and adjacent vertical incisions and CTGs were harvested from the palatal regions. Different from CAF+CTG group, PRF was prepared by obtaining 10 ml venous blood, centrifugation and extraction of the gel containing highly concentrated platelet cells in CAF+CTG+PRF patients. Then the gel was placed over the exposed root surface in the same group. The CAF was primarily closed and postoperative instructions were given. After suture removal at second postoperative week, the patients were followed-up by monthly recall visits. Same periodontal clinical variables were recorded 3 and 6 months after surgery.

Enrollment: 40 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Systemically healthy
• Single Miller type I or II recession defect ≥ 3 mm localized to anterior/premolar area
• No alveolar bone loss
• Identifiable cemento-enamel junction
• Probing depth ≤3mm

Exclusion criteria

• Smoking
• Pregnancy
• History of periodontal surgery in last two years
• Mobility
• Excessive occlusal contacts
• Caries
• Loss of vitality

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

PRF+CAF+CTG

Experimental group

Description:

platelet-rich fibrin + coronally advanced flap + connective tissue graft

Treatment:

Procedure: connective tissue graft

Procedure: coronally advanced flap

Biological: platelet-rich fibrin

CAF+CTG

Active Comparator group

Description:

coronally advanced flap + connective tissue graft

Treatment:

Procedure: connective tissue graft

Procedure: coronally advanced flap