Platelet Rich Fibrin on Root Coverage of Gingival Recessions

Universidad Antonio Nariño

Status: Completed

Conditions: Gingival Recession

Treatments: Other: Platelet rich fibrin

Study type: Interventional

Funder types: Other

Identifiers

NCT04248049

Universidad Antonio Nariño

Details and patient eligibility

About

Several surgical techniques and various adjunctive agents have been used to covered Gingival Recession (GR) and promote clinical outcomes. The treatment of the GR more used (gold standard) is the root coverage with surgical procedures and connective tissue graft, but it has limitations due to the conditions of the donor graft. Is necessary develop other biomaterials for these cases.

The platelet rich fibrin is a autologous biomaterial that has gained tremendous momentum having been utilized for a variety of dental and medical procedures including periodontal surgeries. However, results remain contradictory and mainly focus on the hard and soft tissue healing, aesthetics and postoperative discomfort.

The objective of this study was to evaluate the clinical effects of coronal advanced flap (CAF) and CAF + Platelet Rich Fibrin (PRF) on Root coverage (RC) over a period of 24 month.

Enrollment: 15 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participant is willing and able to give informed consent for participation in the study
• Healthy males and females of age 18-60 years old
• Multiple bilateral (maxillary or mandibular) gingival recessions (Miller class І or II)
• Good oral hygiene (O´Leary index ≤ 15%)

Exclusion criteria

• Active periodontal disease
• Periodontal surgeries in the last three years
• Pregnancy or lactation
• Smokers or alcoholics
• Platelet dysfunction syndrome or thrombocytopenia
• Coagulation defects
• Uncontrolled diabetes
• Medical contraindications to elective oral surgery procedures
• Severe immunodeficiencies
• Oncological history
• Prosthetic restorations adjacent to gingival recessions
• Mobility II or III
• Occlusal contacts excessive
• Root caries
• Buccal restaurations Class V

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

15 participants in 2 patient groups

Experimental side

Experimental group

Description:

Roots covered with coronally advanced flap (CAF) and platelet rich fibrin (PRF) (CAF+PRF)

Treatment:

Other: Platelet rich fibrin

Control side

Active Comparator group

Description:

Roots covered with coronally advanced flap (CAR)

Treatment:

Other: Platelet rich fibrin