Platelet Rich Fibrin Versus Melatonin Around Dental Implants

Misr University for Science and Technology

Status and phase: Completed; Phase 2

Conditions: Patients With Missing Teeth

Treatments: Biological: dental implants with melatonin gel

Study type: Interventional

Funder types: Other

Identifiers

NCT05593731

Misprotocol

Details and patient eligibility

About

Dental implant is a dental treatment that allow oral rehabilitation for partial and fully edentulous patients. Osteointegration is the factor that control success s or failure of dental implant that can be improved by addition of different adjunctive biological materials. Platelets Rich fibrin plays a significant role in tissue regeneration and wound healing. Melatonin is biological hormone that secreted from pineal gland and played an important role in human growth.

Enrollment: 30 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. good oral hygiene participants,
2. free of any systemic diseases,
3. Patients' age ranged from 20 to 40 years old.
4. Patients who can complete surgery and the study protocol.
5. Partially edentulous patients in the posterior mandibular region (at least a single-mandibular edentulous area) with periodontal health.

Exclusion criteria

1. patients who had parafunctional habits,
2. current and former smokers, pregnant
3. lactating women
4. unmotivated patients
5. patients with psychological problems
6. patients who were not able to follow the treatment protocol -

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 3 patient groups

dental implants alone

Other group

Description:

dental implants alone

Treatment:

Biological: dental implants with melatonin gel

platelet rich fibrin

Active Comparator group

Description:

dental implants with platelet rich fibrin membrane

Treatment:

Biological: dental implants with melatonin gel

melatonin gel

Active Comparator group

Description:

dental implants with melatonin gel around dental implants

Treatment:

Biological: dental implants with melatonin gel