Platelet-rich Plasma for Meniscus Repair

Pei-Yuan Lee, MD

Status: Completed

Conditions: Knee Injuries; Meniscus Disorder; Platelet-Rich Plasma

Treatments: Other: control; Other: platelet-rich plasma

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03176641

RA-16027-RD-105063

Details and patient eligibility

About

This study aims to evaluate the effect of platelet-rich plasma (PRP) on meniscus injury by comparing the imaging and clinical outcomes between patients receiving PRP with meniscus repair surgery and those receiving meniscus repair surgery only.

Full description

Damage to meniscal tissue is challenging for orthopedic surgeons because of the absence of healing at the avascular zone. Additionally, the accelerated degeneration of articular cartilage and increased rate of knee osteoarthritis that can occur following a meniscal injury. Platelet-rich plasma (PRP) is a fraction of plasma that contains platelets and multiple growth factors concentrated at high level. Because activated platelets have the potential to release growth factors, PRP has been clinically used to accelerate wound healing and tissue regeneration in orthopedic and oral surgery. Several in vivo and in vitro studies have reported favorable outcomes of PRP on meniscal repair; however, the clinical results varied between studies.This clinical trial will investigate the effect of PRP on on meniscus injury. Eligible patients will be randomly assigned to receive PRP with meniscus repair surgery or to receive meniscus repair surgery only. The postoperative imaging and clinical outcomes will be compared and analyzed.

Enrollment: 60 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 20 and 60 years
• With diagnosis of meniscus injury
• With indications of meniscus repair surgery

Exclusion criteria

• Multiple ligaments injury
• with prior history of knee surgery
• Cancer patients
• Pregnancy
• Patients who will not cooperate with one-year followup

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups, including a placebo group

PRP group

Active Comparator group

Description:

30 patients will receive autologous platelet-rich plasma gel during meniscus repair surgery.

Treatment:

Other: platelet-rich plasma

Control group

Placebo Comparator group

Description:

30 patients will receive meniscus repair surgery only.

Treatment:

Other: control