Platelet-rich Plasma Injection for Ulnar Neuropathy at Elbow

Yung-Tsan Wu

Status: Completed

Conditions: Ulnar Neuropathy at Elbow

Treatments: Drug: 5% dextrose; Drug: platelet-rich plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT04264000

PRP for ulnar neuropathy

Details and patient eligibility

About

Ulnar neuropathy at elbow (UNE) is the second common peripheral entrapment neuropathy after carpal tunnel syndrome (CTS). Although many conservative managements of UNE were found, their effectiveness were often unsatisfied without existed guideline. Recently, the perineural injection of 5% dextrose wate (D5W) is a novel management for CTS but its effect for UNE is not obviously as CTS. Hence, it is very important to find another novel injectate for UNE.

Full description

The platelet-rich plasma (PRP) is a new and potential treatment for patients with kinds of musculoskeletal disorders and recent reports showed being beneficial for peripheral neuropathy in animal studies. Our previous research shown single injection with PRP was superior to D5W for CTS. However there is no study investigating the effect of PRP for UNE now. Hence, the purpose of this study was to assess the effect of perineural PRP injection for UNE.

Enrollment: 30 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age between 20-80 year-old.
2. Diagnosis as ulnar neuropathy at elbow at least one month

Exclusion criteria

1. Cancer

2. Coagulopathy

3. Pregnancy

4. Any active infection status 4. Polyneuropathy of upper extremity 5. Brachial plexopathy 6. Thrombocytopenia Previously undergone wrist surgery or steroid injection for ulnar neuropathy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

platelet-rich plasma

Experimental group

Description:

The perineural injection with PRP is a potential treatment for peripheral entrapment neuropathy

Treatment:

Drug: platelet-rich plasma

5% dextrose

Active Comparator group

Description:

The perineural injection of 5% dextrose is a novel management for peripheral entrapment neuropathy

Treatment:

Drug: 5% dextrose