Platelet-rich Plasma Intra-articular Knee Injections for Knee Osteoarthritis

Vall d'Hebron University Hospital (HUVH)

Status and phase

Completed

Phase 3

Conditions

Knee Osteoarthritis

Treatments

Drug: Corticosteroid

Biological: platelet-rich plasma

Study type

Interventional

Funder types

Other

Identifiers

NCT01381081

PRP2010

2010-023977-21 (EudraCT Number)

Details and patient eligibility

About

The benefit of using platelet rich plasma (PRP) in cartilage injuries, and specifically in degenerative ones, has not been assessed yet. Current studies on the PRP healing or repairing effect on knee cartilage degenerative injuries are not conclusive to establish a standard of behavior, although PRP has shown to improve joint functionality and reduce pain.

Hypothesis: PRP intra-articular injections in osteoarthritic knees reduces pain and leads to a more effective and lasting functional recovering than corticosteroid intra-articular injections.

Enrollment

74 patients

Sex

All

Ages

40 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Degenerative osteoarthritis of the knee confirmed radiologically
Degenerative osteoarthritis of the knee replacement candidate
Walking ability in patients with or without external support
Baseline in pain VAS greater than 60

Exclusion criteria

Neoplastic disease
Immunosuppressive States
Patients who received intra-articular injections of steroids, anesthetic and / or hyaluronic acid in the last 3 months.
Patients who have undergone arthroscopic surgery on the last 3 months
Patients with involvement of bone metabolism except osteoporosis (Paget's disease, renal osteodystrophy, osteomalacia)
Fibromyalgia or chronic fatigue syndrome
Liver disease
Deficit coagulation (blood dyscrasia)
Thrombocytopenia
Anticoagulant treatment