Platelet Rich Plasma (PRP) as a Treatment for Knee Osteoarthritis PRP as a Treatment for Knee Osteoarthritis

Clalit Health Services

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Osteoarthritis of the Knee

Treatments: Biological: Platelet Rich Plasma (Preparation Rich in Growth Factors); Drug: Hyaluronic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT01270412

MMC10196-2010CTIL

Details and patient eligibility

About

Autologous platelet-secreted growth factors (GFs) may have therapeutic effects in osteoarthritis (OA) capsular joints via multiple mechanisms. The aim is to examine the effect of a platelet-derived preparation rich in growth factors (PRGFs) in OA of the knee.

Full description

Autologous platelet-secreted growth factors (GFs) may have therapeutic effects in osteoarthritis (OA) capsular joints via multiple mechanisms. The investigators aim is to examine the effect of a platelet-derived preparation rich in growth factors(PRGFs) in OA of the knee, using parameters of pain, function, quality of life and safety.

Enrollment: 100 estimated patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 40-75 years old
• diagnosed Oa of the knee more then 1 year
• no knee deformation

Exclusion criteria

• mental of physical disabilities
• pregnancy
• deformities of the knee

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

Platelet Rich Plasma (Preparation Rich in Growth Factors)

Experimental group

Description:

intra articular injection 6ml of platelet-derived preparation rich in growth factors

Treatment:

Biological: Platelet Rich Plasma (Preparation Rich in Growth Factors)

Hyaluronic acid

Active Comparator group

Description:

Drug: hyaluronic acid 20 mg / 2 ml Other Name: Arthrease

Treatment:

Drug: Hyaluronic acid

Biological: Platelet Rich Plasma (Preparation Rich in Growth Factors)