Platelet Transfusion in Sepsis Trial

University Hospital Tuebingen

Status: Withdrawn

Conditions: Thrombocytopenia; Sepsis

Treatments: Biological: platelet transfusion

Study type: Interventional

Funder types: Other

Identifiers

NCT03968484

PlaTiSep

Details and patient eligibility

About

Platelets are important mediators of an inflammatory response and a key component of the innate immune system to defend the human body against invading pathogens. However, little evidence exists regarding the number of platelets that should be used als transfusion threshold in septic patients. In this trial platelet transfusion will be performed with either <50000/µl or <20000/µl as a trigger.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Sepsis defined as alteration of SOFA score (Sepsis-related organ failure assessment score) >2 points (Sepsis-3 definition)
• platelet count <50.000/µl

Exclusion criteria

• Age less than 18 years
• patients with immune thrombocytopenia
• major bleeding in the last 72 hours or ongoing major bleeding
• patient, surrogate or physician not committed to full intensive care support
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

<50.000/µl

Experimental group

Description:

Transfusion of platelets starting with a platelet count \<50.000/µl

Treatment:

Biological: platelet transfusion

<20.000/µl

Experimental group

Description:

Transfusion of platelets starting with a platelet count \<20.000/µl

Treatment:

Biological: platelet transfusion