Platelets Antiaggregation Control Enhancement (PACE) Study

Cardiochirurgia E.H.

Status: Terminated

Conditions: Blood Transfusion; Bleeding

Treatments: Device: Thromboelastography Alone; Device: Aggregometry+Thromboelastography

Study type: Interventional

Funder types: Other

Identifiers

NCT01218074

00-04

Details and patient eligibility

About

Many patients undergo cardiac surgery without proper suspension of antiaggregation drugs. This is blamed to increase dramatically bleeding and use of allogenic blood transfusions. The investigators test the hypothesis that routine use of aggregometry could show antiaggregated patient and lead to normalization of platelet function via administration of Desmopressin thus limiting bleeding and transfusions.

Enrollment: 200 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• all patients undergoing surgical myocardial revascularization.

Exclusion criteria

• none.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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200 participants in 2 patient groups

Thromboelastography alone

Active Comparator group

Description:

Patients undergo standard of care Thromboelastography to evaluate overall coagulation performances.

Treatment:

Device: Thromboelastography Alone

Aggregometry+Tromboelastography

Experimental group

Description:

Patients undergo standard thromboelastography and subsequent aggregometry to test effectiveness of residual antiaggregation drugs. Patients found to have altered value undergo optimization with desmopressin.

Treatment:

Device: Aggregometry+Thromboelastography