Platelets in Cystic Fibrosis Lung Inflammation

Mersin Training and Research Hospital

Status: Completed

Conditions: Platelet Levels and Mean Platelet Volume in Patients With CF

Treatments: Other: platelet count and mean platelet volume are obtained from whole blood count

Study type: Observational

Funder types: Other

Identifiers

NCT05339724

2022/138

Details and patient eligibility

About

Cystic fibrosis (CF) is a chronic multiorgan disorder caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene. Chronic airway infection by bacterial pathogens accounts for the progressive, suppurative pulmonary disease that leads to significant morbidity and mortality in patients with CF. Neutrophil recruitment to the lungs accounts the most important contributor to pulmonary destruction. However, there is evidence that platelets may also have an important role in the pathogenesis of inflammation. To our knowledge, there is few information in platelet levels in patients with cystic fibrosis during pulmonary exacerbation, chronic airway colonization and when stable.

Full description

Airway inflammation in CF is predominantly neutrophilic in nature with increased concentrations of pro-inflammatory mediators include TNF-α, IL-1β, IL-6, IL-8, IL-17, IL-33, GM-CSF and G-CSF. In addition, other cell types including macrophages and T-lymphocytes are expressed by CFTR and contribute to the CF inflammatory response.

Researches have indicated that platelets may also have a significant contribution to the inflammation. Platelet depletion or antiplatelet therapies attenuate injury and mortality in animal models of acute lung injury. More importantly, CFTR expression has been shown on human platelets. Recent data suggests that CF patients have an increase in circulating activated platelets and platelet reactivity.

Taken together, these observations support a potentially important role of platelets in regulating lung inflammation in CF. However, there are few studies examine platelet and lung inflammation interraction in patients with CF. Therefore we aimed to investigate platelet count (PC) and mean platelet volume (MPV) levels in various conditions in our CF patients.

Enrollment: 53 patients

Sex: All

Ages: 12 months to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All regularly followed cystic fibrosis patients with clinical and laboratory results could be obtained from medical charts.

Exclusion criteria

• None

Trial design

53 participants in 6 patient groups

Group 1. Total cystic fibrosis patients with pulmonary exacerbation

Description:

Platelet count (PC) and mean platelet volume (MPV) during pulmonary exacerbation.

Treatment:

Other: platelet count and mean platelet volume are obtained from whole blood count

Group 2. Total cystic fibrosis patients with no pulmonary exacerbation

Description:

PC and MPV during no pulmonary exacerbation

Treatment:

Other: platelet count and mean platelet volume are obtained from whole blood count

Group 3. Cystic fibrosis patients with chronic colonization in acute pulmonary exacerbation

Description:

PC and MPV during chronic colonization in acute pulmonary exacerbation

Treatment:

Other: platelet count and mean platelet volume are obtained from whole blood count

Group 4. Cystic fibrosis patients with chronic colonization without pulmonary exacerbation

Description:

PC and MPV during chronic colonization without pulmonary exacerbation

Treatment:

Other: platelet count and mean platelet volume are obtained from whole blood count

Group 5. Cystic fibrosis patients with chronic colonization without pulmonary exacerbation

Description:

PC and MPV during chronic colonization without pulmonary exacerbation

Treatment:

Other: platelet count and mean platelet volume are obtained from whole blood count

Group 6. Cystic fibrosis patients with no chronic colonization without pulmonary exacerbation

Description:

PC and MPV during no chronic colonization without pulmonary exacerbation

Treatment:

Other: platelet count and mean platelet volume are obtained from whole blood count