Platinum for Triple-Negative Metastatic Breast Cancer and Evaluation of p63/p73 as a Biomarker of Response

Mass General Brigham

Status and phase

Completed

Phase 2

Conditions

Breast Cancer

Treatments

Drug: Cisplatin

Drug: carboplatin

Study type

Interventional

Funder types

Other

Identifiers

NCT00483223

06-412

TBCRC009 (Other Identifier)

Details and patient eligibility

About

The purpose of this research study is to :

Determine how effective cisplatin or carboplatin is in slowing the time it takes for ER negative (estrogen-receptor-negative), PR negative (progesterone receptor-negative), HER2 negative (human epidermal growth factor receptor 2) breast cancer to progress. Cisplatin and carboplatin are anti-cancer chemotherapy drugs that stop cancer cells from growing abnormally and is used to treat other cancers.
Evaluate a new biomarker to help determine which breast cancers are most likely to respond to cisplatin chemotherapy

The hypothesis is that Triple Negative metastatic breast cancer may be particularly sensitive to platinum, and that a subgroup of those patients may have a marker in their tumors that predicts response.

Full description

This study is a Phase 2 study designed to evaluate cisplatin/carboplatin as first or second line therapy in metastatic triple negative (ER negative, PR negative, Her2 Negative) breast cancer and to evaluate the expression of p63/p73 as a biomarker to predict response.

Participants will be given a cisplatin or carboplatin infusion intravenously on the first day of each treatment cycle. Each treatment cycle will last 3 weeks. Treating physician will select agent up to 41 patients in each cohort. Final primary endpoint analysis will use combined cis/carbo results.
During all treatment cycles participants will have a physical exam (including weight and vital signs) and they will be asked general questions about their health and any medications they may be taking, as well as specific questions about any side effects they may be experiencing while receiving study treatment.
During every treatment cycle participants will have standard blood tests to check blood counts, liver and kidney function, and a blood marker for you particular type of cancer.
CT scans will be taken of the participants tumor every 2 to 3 cycles to assess the response of the tumor to cisplatin.
Participants will be in this study for as long as they tolerate the study treatment and their disease does not get any worse.
Participants will be required to have a sample of their original tumor sent to Massachusetts General Hospital for correlative studies, or a sample from a metastatic diagnostic biopsy.
Patients with accessible tumor will be asked to provide an optional metastatic tumor biopsy for correlative studies.

Enrollment

86 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically confirmed invasive breast cancer with stage IV disease, according to AJCC 6th edition (American Joint Committee on Cancer), either biopsy proven or with unequivocal evidence of metastatic disease by physical examination or radiological study
All tumors must be ER-, PGR- and HER2-negative
18 years of age or older
Paraffin tissue block is required from the primary tumor tissue or from diagnostic metastatic biopsy at time of relapse
Measurable disease by RECIST
Performance status of 0,1 or 2 by ECOG criteria (Eastern Cooperative Oncology Group)
Life expectancy greater than 12 weeks
Normal organ and bone marrow function documented within 14 days prior to enrollment as defined by the protocol

Exclusion criteria

More than 1 prior chemotherapy for the treatment of recurrent or metastatic breast cancer
Prior treatment with cisplatin, carboplatin, or other platinum chemotherapy agents
Active brain metastases or unevaluated neurological symptoms suggestive of brain metastases
Intercurrent illness or other major medical condition or comorbid condition that might affect study participation
Significant history of uncontrolled cardiac disease such as uncontrolled hypertension, unstable angina, recent myocardial infarction, uncontrolled congestive heart failure, cardiomyopathy either symptomatic or asymptomatic but with decreased ejection fraction <45%
Renal dysfunction for which cisplatin dose would either require dose modification or would be considered unsafe
Pregnant or nursing women
History or other malignancy that was not treated with curative intent