Pneumocystis in Patients Over 75 Year (C_PAPY)

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Pneumocystis

Study type: Observational

Funder types: Other

Identifiers

NCT07004127

IRB_22.01.05

Details and patient eligibility

About

Pneumocystis pneumonia is an infectious disease caused by Pneumocystis jirovecii that affects the lung parenchyma preferentially. Historically described in an immunocompromised population through HIV.

Worldwide, the profile of patients affected by this pathology is changing due to two main factors:

• The sustainable stabilization of HIV patients.
• The emergence of new risk factors of immunosuppression. The geriatric population is particularly affected by these risk factors, increasing the incidence of pneumocystis in this population, which does not have HIV (solid cancer, hemopathy, immunosuppressive treatments, etc.).

There is currently no work specifically studying pneumocystis in this age group. The main objective of this study is to describe the clinical, biological and therapeutic data of a cohort of geriatric patients with pneumocystis, not carrying HIV, from January 1, 2010 to December 31, 2021, in all the centers surveyed.

Enrollment: 162 patients

Sex: All

Ages: 75+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

1. Patient > or equal to 75 years of age

2. Microbiological diagnosis:

   • Direct examination with standard stain, finding trophozoite and/or P.jirovecii cyst (BAL or induced sputum) And/or
   • Direct examination with immunofluorescence, finding trophozoite and/or P.jirovecii cyst (BAL or induced sputum)
   • And/or
   • Positive PCR (BAL, sputum, nasopharyngeal swab or blood) and CT < 35

3. Absence of HIV infection

4. Hospitalization in French hospitals between 2010 and 2021

Non-inclusion criteria

1. Opposition of the patient to participate to the study

Trial design

162 participants in 1 patient group

geriatric patient with pneumocystis

Description:

geriatric patient with pneumocystis, not HIV positive,