Pneumocystis Jirovecii Pneumonia in Non-HIV-infected Immunocompromised Patients (PnP-HIV-Free)

Central Hospital, Nancy, France

Status: Completed

Conditions: Pneumocystis Jirovecii Infection

Study type: Observational

Funder types: Other

Identifiers

NCT05458752

2020PI184-Pre-existing datas

Details and patient eligibility

About

Pneumocystis jirovecii pneumonia (PjP) is a rare infectiouse disease with a high level of mortality. PjP is a classical opportunistic infection which concern HIV infected and immunocompromised patients. During the past decade, several therapeutic's progresses have been done in oncology, immunology and hematology. As a consequence, patients benefited of greater treatment efficacy but are exposed to a higher risk of opportunistic infections as PjP. The investigators hypothesis is that PjP incidence increase and its form is depending of underlying immune conditions. The investigators aim to describe its incidence, the PjP forms depending on comorbidities and to identifiy pronostics factors.

Enrollment: 133 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Underlying immune condition at risk of Pneumocystis jirovecii pneumonia excluding HIV infection
• Clinical, biological and radiological presentation which evoke Pneumocystis jirovecii pneumonia
• Microbiological confirmation by respiratory specimen analyses ( specific coloration and/or IFI and/or PRC)

Exclusion criteria

• No microbiological confirmation by respiratory specimen analyses
• Proved HIV infection
• Patient denied to particpate