POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

Xuzhou Medical University

Status: Completed

Conditions: Postoperative Cognitive Dysfunction

Study type: Observational

Funder types: Other

Identifiers

NCT03084393

XYFY2017-KL004-01

Details and patient eligibility

About

To study on the Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12. To explore whether the gene polymorphism and the concentrations of plasma homocysteine, folic acid and vitamin B12 could be used as predictor(s) of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.

Enrollment: 215 patients

Sex: All

Ages: 60 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-cardiac surgery patients;
• Age is greater than or equal to 60 years old;
• Han Nationality, mother tongue is chinese;
• The MMSE score: Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;
• The Geriatric Depression Scale (GDS) grade 1 or 2;
• The important function without serious heart, brain, liver, kidney, lung and other organs;
• The ASA class I or II;
• The people signed informed consent.

Exclusion criteria

• The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.;
• Had severe head and face disease, trauma history or history of surgery;
• The serious body disease and tobacco, wine and other substance abuse history;
• The presence of malignant tumor with shorter survival disease.

Trial design

215 participants in 2 patient groups

study group

Description:

215 Male and female patients undergoing non-cardiac surgery at the Affiliated Hospital of Xuzhou Medical University \[Jiangsu China\]. The investigators do the Mini-Mental score examination (MMSE) and neuropsychological tests 1 day before (baseline) and 1 week after surgery without safety issue. Patients will be divided into POCD and non-POCD groups according to the two times tests.

non-surgical group

Description:

The investigators enroll 30 healthy volunteers and do the Mini-Mental score examination (MMSE) and neuropsychological tests at 1 day (baseline) and1 week without safety issue. The exclusive purpose of the non-surgical group is to aid in the POCD calculation according to the ISPOCD 1 study definition.