POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

Loma Linda University (LLU)

Status: Completed

Conditions: 1. Postoperative Cognitive Dysfunction

Treatments: Other: The intervention will be Mini-Mental Status Examination (MMSE)

Study type: Observational

Funder types: Other

Identifiers

NCT01199913

5100193

Details and patient eligibility

About

The use of desflurane in elderly subjects (>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's baseline and the cerebral suppression state index stays within the moderately anesthetized range during general anesthesia.

Enrollment: 110 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (>65 years old)
• Scheduled for elective surgery requiring general anesthesia at LLUMC HSH
• Airway management expected to include endotracheal intubation
• Expected surgical duration 120 to 240 minutes

Exclusion criteria

• Pre-existing significant psychiatric disease or mental status changes

• Clinically significant cardiovascular, respiratory, hepatic, renal,neurological, psychiatric, or metabolic disease

• Patient's weighing >50% ideal body weight

  • Men: Ideal Body Weight (in kilograms) = 50 + 2.3 kg per inch over 5 feet
  • Women: Ideal Body Weight (in kilograms) = 45.5 + 2.3kg per inch over 5 feet

• Patients who have undergone a general anesthetic within the past 7 days

• Patient refusal

Trial design

110 participants in 1 patient group

desflurane and sevoflurane

Description:

Subjects will be randomized to either desflurane or sevoflurane. They will be given the Mini Mental State exam at 1, 6 and 24 hours after the end of anesthesia.

Treatment:

Other: The intervention will be Mini-Mental Status Examination (MMSE)