Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney Injury

Post Graduate Institute of Medical Education and Research, Chandigarh

Status: Active, not recruiting

Conditions: AKI; Acute-On-Chronic Liver Failure; Refractory Ascites; Cirrhosis, Liver; Hepatorenal Syndrome

Treatments: Diagnostic Test: Echocardiographic assessment

Study type: Observational

Funder types: Other

Identifiers

NCT05434286

IM-2020-2145

Details and patient eligibility

About

Point-of-care echocardiography (POC-Echo) is used to determine left ventricular systolic and diastolic dysfunction (LVDD), inferior vena cava (IVC) dynamics and volume status in cirrhosis and Acute-on-chronic liver failure ACLF accurately.

We will assess IVC dynamics, LV systolic function [LV ejection fraction (EF) & cardiac output (CO)], and diastolic dysfunction (E/e', e' and E/A ratio) and urinary biomarkers (cystatin C and NGAL) in patients with cirrhosis and ACLF with hepatorenal syndrome-acute kidney injury (HRS-AKI).

Enrollment: 75 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cirrhosis of any Etiology
• Patient with acute kidney injury meeting HRS-AKI criteria

Exclusion criteria

• Hepatocellular carcinoma
• Patients with active variceal bleeding
• HIV or severe immunocompromised state
• Chronic kidney disease (CKD) on renal replacement therapy (RRT),
• Previous transjugular intra hepatic portosystemic shunt (TIPS)
• Porto-pulmonary hypertension,
• Coronary artery disease
• Congenital or valvular heart disease
• Prosthetic cardiac valves

Trial design

75 participants in 1 patient group

Cirrhosis/ACLF of any etiology

Description:

Cirrhosis with hepatorenal syndrome-acute kidney injury (HRS-AKI) as per International Ascites Club criteria.

Treatment:

Diagnostic Test: Echocardiographic assessment