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Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney Injury

P

Post Graduate Institute of Medical Education and Research, Chandigarh

Status

Active, not recruiting

Conditions

AKI
Acute-On-Chronic Liver Failure
Refractory Ascites
Cirrhosis, Liver
Hepatorenal Syndrome

Treatments

Diagnostic Test: Echocardiographic assessment

Study type

Observational

Funder types

Other

Identifiers

NCT05434286
IM-2020-2145

Details and patient eligibility

About

Point-of-care echocardiography (POC-Echo) is used to determine left ventricular systolic and diastolic dysfunction (LVDD), inferior vena cava (IVC) dynamics and volume status in cirrhosis and Acute-on-chronic liver failure ACLF accurately.

We will assess IVC dynamics, LV systolic function [LV ejection fraction (EF) & cardiac output (CO)], and diastolic dysfunction (E/e', e' and E/A ratio) and urinary biomarkers (cystatin C and NGAL) in patients with cirrhosis and ACLF with hepatorenal syndrome-acute kidney injury (HRS-AKI).

Enrollment

75 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Cirrhosis of any Etiology
  • Patient with acute kidney injury meeting HRS-AKI criteria

Exclusion criteria

  • Hepatocellular carcinoma
  • Patients with active variceal bleeding
  • HIV or severe immunocompromised state
  • Chronic kidney disease (CKD) on renal replacement therapy (RRT),
  • Previous transjugular intra hepatic portosystemic shunt (TIPS)
  • Porto-pulmonary hypertension,
  • Coronary artery disease
  • Congenital or valvular heart disease
  • Prosthetic cardiac valves

Trial design

75 participants in 1 patient group

Cirrhosis/ACLF of any etiology
Description:
Cirrhosis with hepatorenal syndrome-acute kidney injury (HRS-AKI) as per International Ascites Club criteria.
Treatment:
Diagnostic Test: Echocardiographic assessment

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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