Point of Care Testing of Cholinesterase Activity During Burn- and Polytrauma (POCCET)

University Hospital Heidelberg

Status: Completed

Conditions: Trauma; Burns

Study type: Observational

Funder types: Other

Identifiers

NCT02691650

Burns and Trauma POC ChE Study

Details and patient eligibility

About

Goal of this study is to measure serum cholinesterase activity in patients with traumatic and/or burns injury admitted to the emergency room by using point-of- care-test system (POCT). Serum cholinesterase activity, measured using POCT system, might play an important role in the early diagnosis and prediction of patient outcome in trauma-induced systemic inflammation.

Enrollment: 85 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• signed written consent
• 18 years and older
• severe trauma (ISS > 15)
• burns injury (2. degree more than 15% body surface or 3 degree more than 10% body surface)
• SIRS

Exclusion criteria

• not fulfilling the inclusion criteria
• failure to adhere

Trial design

85 participants in 2 patient groups

polytrauma patients

Description:

Patients with severe traumatic injury, admitted to the emergency unit. Serum cholinesterase activity measurement using 10 µl whole blood, otherwise obtained through routine blood gas analysis upon arrival to the hospital.

burns patients

Description:

Patients with burns trauma, admitted to the emergency unit. Serum cholinesterase activity measurement using 10 µl whole blood, otherwise obtained through routine blood gas analysis upon arrival to the hospital.