Polarization Sensitive Optical Coherence Tomography

Singapore Eye Research Institute

Status: Completed

Conditions: Myopia

Treatments: Device: Polarization sensitive optical coherence tomography (PS-OCT)

Study type: Observational

Funder types: Other

Identifiers

NCT05809674

R1819/61/2021

Details and patient eligibility

About

The purpose of the study is to use the polarization sensitive optical coherence tomography (PS-OCT) developed by Singapore Eye Research Institute, to evaluate the potential OCT scleral biomarkers capable of predicting risk of myopia progression.

Enrollment: 178 patients

Sex: All

Ages: 10 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

(Adult Cohort)

• Aged 21 and above
• Ability to provide informed consent
• 42 normal controls: No diabetes and free from clinically relevant eye disease that interferes with the aim of the study i.e. glaucoma, diabetic retinopathy, age-related macular degeneration, uveitis, or vascular occlusive diseases
• 76 subjects with pathological myopia (up to -12 dioptres) or staphyloma

(Children Cohort)

• Aged 10 to 18
• 23 subjects with low to moderate myopia (-0.75 to -6 dioptres)
• 23 subjects with high myopia (more than -6 dioptres)
• Ability of legal representative and subject to provide informed consent

Exclusion criteria

(Adult Cohort)

• Unable to give consent
• Subjects with visual acuity worse than 6/12
• Diagnosis of clinically relevant eye disease that interferes with the aim of the study (e.g. diabetic retinopathy, hereditary macular disease, glaucoma, uveitis, or vascular occlusive diseases) or conditions that may potentially result in poor quality imaging scans (severe cataract, corneal haze/opacity)

Trial design

178 participants in 2 patient groups

Adult Cohort

Description:

* Aged 21 and above * Ability to provide informed consent * 42 normal controls: No diabetes and free from clinically relevant eye disease that interferes with the aim of the study i.e. glaucoma, diabetic retinopathy, age-related macular degeneration, uveitis, or vascular occlusive diseases * 76 subjects with pathological myopia (up to -12 dioptres) or staphyloma

Treatment:

Device: Polarization sensitive optical coherence tomography (PS-OCT)

Children Cohort

Description:

* Aged 10 to 18 * 23 subjects with low to moderate myopia (-0.75 to -6 dioptres) * 23 subjects with high myopia (more than -6 dioptres) * Ability of legal representative and subject to provide informed consent

Treatment:

Device: Polarization sensitive optical coherence tomography (PS-OCT)