Polymorphids an mRNA Expression in Obese Genes

Karolinska Institute

Status: Completed

Conditions: Polymorphism; mRNA Expression

Study type: Observational

Funder types: Other

Identifiers

NCT01708083

2009/1629-31/3

Details and patient eligibility

About

Fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (GBP).

Are there any difference in polymorphids and/or mRNA expression in genes significant for developing obesity, between normal weight and obese individuals, with or without diabetes typ 2 .

Are there any difference in polymorphids and/or mRNA expression in different types of fat tissue

Enrollment: 50 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18 years or older
• laparoscopic surgery (Gastric by-pass, cholecystectomy, antireflux surgery)
• Normal weight without type 2 diabetes BMI 18-25
• Obese without type 2 diabetes BMI>35
• Obese with type 2 diabetes BMI>35

Exclusion criteria

• under 18 years
• open surgery
• pregnancy
• BMI >27-<35

Trial design

50 participants in 3 patient groups

Type 2 Diabetes and BMI>35

Description:

Patients with type 2 diabetes and body mass index 35 or more.

BMI>35

Description:

Patients undergoing surgery, gastric bypass or cholecystectomy, without diabetes type 2 and body mass index 35 or more

BMI 18-27

Description:

Patients undergoing surgery, cholecystectomy or reflux, without type 2 diabetes and body mass index between 18-27