Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis

Polak David

Status: Unknown

Conditions: Periodontal Disease

Treatments: Other: blood extraction

Study type: Interventional

Funder types: Other

Identifiers

NCT02010307

davidp-HMO-CTIL

Details and patient eligibility

About

aggressive periodontitis is an inflammatory disease which damage the teeth supporting structures mostly in young patients. and has genetic basis.

a specific bacteria: Aggregatibacter actinomycetemcomitans (Aa) is associated with this disease, and found to damage leukocytes by using a specific leukotoxin.

in the research the investigators are aiming to find molecular and immunological basis to aggressive periodontitis.

Enrollment: 75 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients in periodontal department
• healthy
• diagnosed with chronic/aggressive periodontal disease
• interested in participating the research

Exclusion criteria

• diagnosed with diabetes, heart disease, immunosuppression, thrombocytopenia, clotting enzyme deficiency.
• using alcohol, or drugs
• pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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75 participants in 3 patient groups

aggressive periodontitis

Experimental group

Description:

25 patients with aggressive periodontitis blood extraction

Treatment:

Other: blood extraction

chronic periodontitis

Experimental group

Description:

25 patients with chronic periodontitis blood extraction

Treatment:

Other: blood extraction

healthy

Experimental group

Description:

25 healthy periodontal patients blood extraction

Treatment:

Other: blood extraction