Polypharmacy and Outcomes After Elective Noncardiac Surgery

Ottawa Hospital Research Institute

Status: Completed

Conditions: Polypharmacy; Morality; Epidemiology; Surgical Procedure, Operative

Treatments: Drug: Polypharmacy

Study type: Observational

Funder types: Other

Identifiers

NCT03133182

DM5

Details and patient eligibility

About

This study investigates the association of preoperative polypharmacy with outcomes and healthcare resource utilization in a population-based sample of older patients enrolled in a universal pharmacare program

Full description

Multilevel multivariable regression analysis will be used to investigate the adjusted association between preoperative polypharmacy and postoperative outcomes and healthcare resource utilization. Sensitivity analyses will be used to evaluate the robustness of the primary analysis.

Enrollment: 266,499 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Intermediate to high risk elective non-cardiac surgery
• Age >=66 on day of surgery

Exclusion criteria

Trial design

266,499 participants in 2 patient groups

Polypharmacy

Description:

People taking \>=5 unique prescription drugs in the 3 months prior to surgery

Treatment:

Drug: Polypharmacy

No polypharmacy

Description:

People taking \<5 unique prescription drugs in the 3 months prior to surgery