Polyphenols, Exercise, and Metabolomics

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Appalachian State University

Status

Completed

Conditions

Exercise-induced Inflammation
Exercise-induced Oxidative Stress
Exercise-induced Immune Dysfunction

Treatments

Dietary Supplement: Nutrasorb
Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT01775384
12-0134

Details and patient eligibility

About

Nutrasorb is a newly developed food product (see www.nutrasorb.com). This study will use the Nutrasorb soy protein product that is matrixed with polyphenols from blueberries and green tea extract, and test for efficacy as a nutritional countermeasure to exercise-induced physiologic stress (i.e., immune dysfunction, inflammation, and oxidative stress) using both traditional and metabolomics-based outcome measures.

Enrollment

34 patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Male or female endurance athletes; competitive runners or cyclists
  • Capable of exercising for 2.5 h at a high intensity in the lab
  • Ages 18-55
  • Agree to train normally and stay weight stable.
  • Agree to avoid the use of large dose vitamin/mineral supplements
  • Agree to avoid herbs and medications that influence inflammation

Exclusion criteria

  • Regularly take supplements or medicines known to effect inflammation.
  • At moderate or high risk for cardiovascular disease.
  • Younger than 18 or older than 55 years of age.
  • No history of competing in long distance running and cycling races.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

34 participants in 2 patient groups, including a placebo group

Nutrasorb
Experimental group
Description:
Soy protein powder sorbed with polyphenols from blueberries and green tea extract
Treatment:
Dietary Supplement: Nutrasorb
Placebo
Placebo Comparator group
Description:
Soy protein isolate powder without polyphenols (with food coloring)
Treatment:
Dietary Supplement: Placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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