Polyphenols, Exercise, and Metabolomics

Appalachian State University

Status: Completed

Conditions: Exercise-induced Inflammation; Exercise-induced Oxidative Stress; Exercise-induced Immune Dysfunction

Treatments: Dietary Supplement: Nutrasorb; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01775384

12-0134

Details and patient eligibility

About

Nutrasorb is a newly developed food product (see www.nutrasorb.com). This study will use the Nutrasorb soy protein product that is matrixed with polyphenols from blueberries and green tea extract, and test for efficacy as a nutritional countermeasure to exercise-induced physiologic stress (i.e., immune dysfunction, inflammation, and oxidative stress) using both traditional and metabolomics-based outcome measures.

Enrollment: 34 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male or female endurance athletes; competitive runners or cyclists
• Capable of exercising for 2.5 h at a high intensity in the lab
• Ages 18-55
• Agree to train normally and stay weight stable.
• Agree to avoid the use of large dose vitamin/mineral supplements
• Agree to avoid herbs and medications that influence inflammation

Exclusion criteria

• Regularly take supplements or medicines known to effect inflammation.
• At moderate or high risk for cardiovascular disease.
• Younger than 18 or older than 55 years of age.
• No history of competing in long distance running and cycling races.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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34 participants in 2 patient groups, including a placebo group

Nutrasorb

Experimental group

Description:

Soy protein powder sorbed with polyphenols from blueberries and green tea extract

Treatment:

Dietary Supplement: Nutrasorb

Placebo

Placebo Comparator group

Description:

Soy protein isolate powder without polyphenols (with food coloring)

Treatment:

Dietary Supplement: Placebo