Pomegranate to Reduce Maternal and Fetal Oxidative Stress and to Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of Membranes

Hillel Yaffe Medical Center

Status: Unknown

Conditions: PPROM

Treatments: Dietary Supplement: pomegranate

Study type: Interventional

Funder types: Other

Identifiers

NCT02069587

0074-13HYMC

Details and patient eligibility

About

Preterm premature rupture of membrane is associated with increased oxidative stress and inflammatory process, enhancing the activity or the availability of antioxidants may modulate the inflammatory response associated with PPROM, thereby reducing oxidative stress and the risk to the fetus. In this study the investigators sought to determine the effects of Pomegranate 1. On the patients (maternal and fetal) oxidative stress and inflammation associated with PPROM. 2. On the time interval from PPROM to delivery and on the patients (fetal )Ph and apger scores

Full description

In this study the investigators sought to determine the effects of Pomegranate 1. On the patients (maternal and fetal )oxidative stress and inflammation associated with PPROM. 2. On the time interval from PPROM to delivery and on the patients (fetal )Ph and apger scores

Enrollment: 200 estimated patients

Sex: Female

Ages: 18 to 44 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pregnant patients
• admitted with PPROM
• between 24-32 weeks of gestation

Exclusion criteria

• Women with contractions
• abruption
• monochorionic multiple pregnancy
• abnormal (non-reassuring) cardiotocogram
• meconium-stained amniotic fluid
• signs of intrauterine infection
• major fetal anomalies
• hemolysis
• elevated liver enzymes
• low platelets (HELLP syndrome); or severe preeclampsia.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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200 participants in 1 patient group

Pomegranate

Experimental group

Description:

The women in this group will drink pomegranate juice

Treatment:

Dietary Supplement: pomegranate