Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance

Shandong University

Status: Enrolling

Conditions: Bacterial Meningitis; Augmented Renal Clearance

Treatments: Drug: meropenem vancomycin ceftazidime ceftriaxone ceftizoxime linezolid

Study type: Observational

Funder types: Other

Identifiers

NCT04771884

2021-ARC-002

Details and patient eligibility

About

The investigator's purpose is to study the population pharmacokinetics of commonly used antimicrobial agents in children of bacterial meningitis with augmented renal clearance and assess dosage individualization feasibility.

Full description

The investigator's purpose is to study the population pharmacokinetics of meropenem, vancomycin, ceftazidime, ceftriaxone, ceftizoxime and linezolid in children of bacterial meningitis with augmented renal clearance and assess dosage individualization feasibility. In this study, the investigator will detect drug concentration in both plasma and cerebrospinal fluid to construct population pharmacokinetics.

Enrollment: 300 estimated patients

Sex: All

Ages: 2 months to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children have been diagnosed with bacterial meningitis with augmented renal clearance (eGFR ≥ 160 mL/(min*1.73m2));
• Age: 2 months-18 years;
• Meropenem, vancomycin, ceftazidime, ceftriaxone, ceftizoxime and/ or linezolid used as part of regular treatment;
• Meropenem, vancomycin, ceftazidime, ceftriaxone, ceftizoxime and linezolid was administered intravenously.

Exclusion criteria

• Patients who die within the treatment cycle;
• Severe congenital malformation;
• Receive other systemic experimental drug therapy;
• Other factors that the researchers consider unsuitable for inclusion.

Trial design

300 participants in 1 patient group

Treatment(meropenem vancomycin ceftazidime ceftriaxone ceftizoxime linezolid)

Description:

The use of antimicrobial agents depends on the clinical practice.

Treatment:

Drug: meropenem vancomycin ceftazidime ceftriaxone ceftizoxime linezolid