Population Pharmacokinetics of Propafenone and Propranolol in Children Patients

Shandong University

Status: Enrolling

Conditions: Arrhythmia

Treatments: Drug: Propafenone and Propranolol

Study type: Observational

Funder types: Other

Identifiers

NCT05463614

2021_Cardiology Drugs_001

Details and patient eligibility

About

The use of propafenone and propranolol in children during clinical treatment was depending mostly on experience. Besides, there was no recommended dose for children in drug instruction. Therefore, the investigators' aim is to study the pharmacokinetics and pharmacodynamics in children.

Enrollment: 500 estimated patients

Sex: All

Ages: 1 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged ≤18years. Parental written consent to participate in the study. Patients treat with Propafenone and Propranolol

Exclusion criteria

• Patients can not complete the research; Abnormal hepatic and renal function; Patient is allergic to propafenone; There are conditions that researchers do not consider it appropriate to join the research.